Contrasting Effects of Vecuronium and Succinylcholine on the Renal Microcirculation in Rodents

  title={Contrasting Effects of Vecuronium and Succinylcholine on the Renal Microcirculation in Rodents},
  author={Sharon R. Inman and Nicholas T. Stowe and Joseph Albanese and Michelle Meehan and J. Victor Ryckman and G G Zanettin and Armin Schubert and P Khairallah},
  journal={Anesthesia \& Analgesia},
We assessed the effects of succinylcholine and vecuronium on renal function and on the renal microcirculation in a rodent model. Vecuronium (0.02 mg/kg followed by 0.2 mg·kg−1·h−1) caused a significant decrease of 16.1% ± 3.87% in inulin clearance from 0.92 ± 0.07 to 0.71 ± 0.05 mL·min−1·gKW−1 (gram of kidney weight), and a decrease in paraaminohippuric acid clearance by 21.6% ± 4.69% from 1.58 ± 0.26 to 1.31 ± 0.20 mL·min−1·gKW−1 (P < 0.05), whereas succinylcholine (0.45 mg/kg followed by 2 mg… Expand
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