Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.

@article{Briolat2014ContrastedIR,
  title={Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.},
  author={Val{\'e}rie Briolat and Luc Jouneau and R. P. L. Carvalho and Nuno R. Palha and Christelle Langevin and Philippe Herbomel and Olivier Schwartz and Herman P. Spaink and J. -P. Levraud and Pierre Boudinot},
  journal={Journal of immunology},
  year={2014},
  volume={192 9},
  pages={
          4328-41
        }
}
Ease of imaging and abundance of genetic tools make the zebrafish an attractive model host to understand host-pathogen interactions. However, basic knowledge regarding the identity of genes involved in antiviral immune responses is still lagging in this species. We conducted a microarray analysis of the larval zebrafish response to two models of RNA virus infections with very different outcomes. Chikungunya virus (CHIKV) induces a rapid and protective IFN response. Infection with infectious… CONTINUE READING
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