Contrast media-induced chromosomal damage in human lymphocyte cultures.

  title={Contrast media-induced chromosomal damage in human lymphocyte cultures.},
  author={Zaheer Parvez and Martti Kormano and Rogelio Moncada and Ritva Eklund},
  journal={Investigative radiology},
  volume={21 11},
Ionic (diatrizoate, ioxaglate) and nonionic (iohexol, iosimide, iopromide, and iotrolan) contrast media (CM) were evaluated for their cytogenetic effects in lymphocytes. Heparinized blood was mixed with culture medium RPMI-1640 supplemented with phytohemagglutinin, fetal calf serum, and antibiotics. Plastic tubes containing blood samples were incubated at 37 degrees C in 5% CO2 humidified air for 48 hours. To these cultures, increasing amounts of CM were added and cells incubated for an… CONTINUE READING


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Advances in Mutagenesis Research

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