Contrast enhanced ultrasound in the detection of liver metastases: a prospective multi-centre dose testing study using a perfluorobutane microbubble contrast agent (NC100100)

@article{Correas2011ContrastEU,
  title={Contrast enhanced ultrasound in the detection of liver metastases: a prospective multi-centre dose testing study using a perfluorobutane microbubble contrast agent (NC100100)},
  author={J. Correas and Gavin Low and Laurence Needleman and Michelle L. Robbin and David Cosgrove and Paul S. Sidhu and Chris J. Harvey and Thomas F Albrecht and Jarl Asbj\orn Jakobsen and Knut Brabrand and Manfred Jenett and Jane Bates and Michel Claudon and E. Leen},
  journal={European Radiology},
  year={2011},
  volume={21},
  pages={1739-1746}
}
To conduct a dose testing analysis of perfluorobutane microbubble (NC100100) contrast-enhanced ultrasound (CEUS) to determine the optimal dose for detection of liver metastases in patients with extra-hepatic primary malignancy. 157 patients were investigated with conventional US and CEUS. CEUS was performed following intravenous administration of perfluorobutane microbubbles (using one dose of either 0.008, 0.08, 0.12 or 0.36 μL/kg body weight). Three blinded off-site readers recorded the… CONTINUE READING

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