Contrast-enhanced CT facilitates rapid, non-destructive assessment of cartilage and bone properties of the human metacarpal.

@article{Lakin2015ContrastenhancedCF,
  title={Contrast-enhanced CT facilitates rapid, non-destructive assessment of cartilage and bone properties of the human metacarpal.},
  author={Bejamin A Lakin and Daniel J. Ellis and Joshua S Shelofsky and Jonathan D. Freedman and Mark W Grinstaff and Brian S. Snyder},
  journal={Osteoarthritis and cartilage},
  year={2015},
  volume={23 12},
  pages={2158-2166}
}
OBJECTIVE The aim of this work is to establish the human metacarpal as a new whole joint surface early-stage osteoarthritis (OA) model that enables comparisons of articular cartilage and subchondral bone through high resolution contrast-enhanced CT (CECT) imaging, mechanical testing, and biochemical analysis. DESIGN The fourth metacarpal was obtained from 12 human cadaveric donors and baseline μCT imaging was followed by indentation testing. The samples were then immersed in anionic… CONTINUE READING