Contraction of guinea pig gall bladder strips by leukotrienes and other agonists.

In the presence of indomethacin, Leukotriene C4 (LTC4), LTD4 and LTE4 were shown to be contractile agents in vitro on guinea pig gall bladder strips. The respective pD2 values for LTC4, LTD4 and LTE4 were 9.1, 9.1 and 7.7. The contractile effects of LTD4 were not mediated through the generation of cyclooxygenase products and were antagonized by the SRS-A… CONTINUE READING