Contraction of bovine coronary vascular smooth muscle induced by cocaine is not mediated by norepinephrine.


This study was designed to assess the effects of cocaine on coronary arterial smooth muscle and to determine whether previously reported cocaine-induced coronary vasospasm is mediated by substances released from the endothelium or by increased adrenergic receptor stimulation. Concentration-response relationships for cocaine (0.1-300 microM) and… (More)


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