Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?

@article{Febbraio2005ContractionInducedMP,
  title={Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?},
  author={M. Febbraio and B. Pedersen},
  journal={Exercise and Sport Sciences Reviews},
  year={2005},
  volume={33},
  pages={114-119}
}
  • M. Febbraio, B. Pedersen
  • Published 2005
  • Biology, Medicine
  • Exercise and Sport Sciences Reviews
  • The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified “myokine” released from muscle that can now be termed an endocrine organ. 
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