Contractility of fatigued diaphragm is improved by dobutamine.

  title={Contractility of fatigued diaphragm is improved by dobutamine.},
  author={Yoshitaka Fujii and Hidenori Toyooka and T Ebata and Keisuke Amaha},
  journal={Canadian journal of anaesthesia = Journal canadien d'anesthesie},
  volume={40 5 Pt 1},
The effects of dobutamine (DOB) on diaphragmatic fatigue were examined in 20 anaesthetized, mechanically ventilated dogs. Animals were divided into two groups: the DOB group (n = 10) and the control group (n = 10). Diaphragmatic fatigue was induced by intermittent supramaximal electric stimulation applied to bilateral phrenic nerves at a frequency of 20 Hz for 30 min. Diaphragmatic contractility was assessed with transdiaphragmatic pressure (Pdi). After diaphragmatic fatigue, Pdi decreased at… CONTINUE READING

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