Contractile stresses in cohesive cell layers on finite-thickness substrates.

Abstract

Using a minimal model of cells or cohesive cell layers as continuum active elastic media, we examine the effect of substrate thickness and stiffness on traction forces exerted by strongly adhering cells. We obtain a simple expression for the length scale controlling the spatial variation of stresses in terms of cell and substrate parameters that describes… (More)
DOI: 10.1103/PhysRevLett.109.108101

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