Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure.

@article{Spann1967ContractileSO,
  title={Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure.},
  author={James F. Spann and R A Buccino and Edmund H. Sonnenblick and Eugene Braunwald},
  journal={Circulation research},
  year={1967},
  volume={21 3},
  pages={341-54}
}
The contractile state of papillary muscles from hypertrophied and from failing right ventricles of cats with pulmonary artery constriction was studied. In muscles from failing hearts, the maximum velocity of shortening, active length-tension curves, and maximum rate of tension development were decreased, while the passive length-tension curves and the time from stimulation to peak tension were normal. The augmentation of isometric tension achieved by paired electrical stimulation, increasing… CONTINUE READING