Corpus ID: 20747853

Contractile serotonergic receptor in rat stomach fundus.

  title={Contractile serotonergic receptor in rat stomach fundus.},
  author={M. Cohen and L. A. Fludzinski},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={243 1},
Serotonin (5HT) is a potent agonist in contracting the rat stomach fundus although the nature of the receptor mediating the response has not been established. The present study was designed to explore the possibility that 5HT-induced contractions in the rat stomach fundus were mediated by interaction with receptors identical with either 5HT1A, 5HT1B or 5HT1C binding sites or 5HT3 receptors. Contractile concentration-response curves for several 5HT agonists [5-carboxamidotryptamine, TR3369… Expand
Characterization of the Contractile 5HT Receptor in the Rat Stomach Fundus
Serotonin is a potent contractile agonist in the rat stomach fundus (ED50 = 3.0 nM). Contraction to serotonin in the fundus was not associated with the indirect release of acetylcholine orExpand
Regional and functional differences of 5-hydroxytryptamine-receptor subtypes in guinea pig stomach.
Functions and the presence of 5-hydroxytryptamine (5-HT) receptors in the fundus, corpus and antrum of the guinea pig stomach were examined by measuring contractile force and acetylcholine (ACh)Expand
Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach.
It is concluded that contractile responses to 5-HT in the antrum are mediated by 5- HT receptors on both smooth muscle and neurons whilst in the corpus and fundus responses are mainly mediated by5-HT receptors on smooth muscle. Expand
Is Contraction to Serotonin Mediated Via 5-HT1C Receptor Activation in Rat Stomach Fundus?
Although serotonin potently contracts the rat stomach fundus, characterization of the receptor responsible for this contraction has not yet been established. Several lines of pharmacological evidenceExpand
Effects of the dopamine receptor agonists, fenoldopam and quinpirole, in the rat stomach.
No evidence was found for the presence of inhibitory dopamine receptors in rat gastric muscle and the contractile effect of fenoldopam in the longitudinal muscle of the fundus is probably due to an interaction with 5-HT receptors. Expand
Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.
The results suggest that the contractile action of 5-MOT in rat stomach fundus involves atropine-sensitive and atropin-resistant components, whereas the resistant contraction is mediated through 5-HT4 receptors located on non-cholinergic neurons and through5-HT2B receptors. Expand
Further Definition of the 5-HT Receptor Mediating Contraction of Rat Stomach Fundus: Relation to 5-HT 1D Recognition Sites
The 5-HT receptor mediating contraction of rat stomach fundus is designated 5-HT1 -like but has defied classification in terms of the recognized subtypes of the high affinity 3H-5-HT binding sites.Expand
Novel 5-HT2-like receptor mediates neurogenic relaxation of the guinea-pig proximal colon.
The aim of the current investigation was to characterize the 5-HT receptors that mediate neurogenic relaxation of the guinea-pig proximal colon and it is suggested that the5-HT receptor under study could be considered an unknown 5- HT2-like receptor. Expand
Pharmacological profile of the 5-hydroxytryptamine receptor that mediates relaxation of rat oesophageal smooth muscle.
It is concluded that the inhibitory 5-HT receptor in rat oesophageal smooth muscle may represent a high affinity subtype which is sensitive to 5- HT3/5-HT4 antagonists and is coupled to the cyclic AMP pathway. Expand
Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron).
The activity of BRL 43694 (granisetron) was investigated using established models of 5-HT3 receptor activity and it was demonstrated that in radioligand binding studies on rat brain membranes, B RL 43694 had little or no affinity for 5- HT1A,5-HT1B, 5-ht2 or for many other binding sites. Expand