Contractile ring-independent localization of DdINCENP, a protein important for spindle stability and cytokinesis.

@article{Chen2006ContractileRL,
  title={Contractile ring-independent localization of DdINCENP, a protein important for spindle stability and cytokinesis.},
  author={Qian Chen and Hui Li and Arturo De Lozanne},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 2},
  pages={
          779-88
        }
}
Dictyostelium DdINCENP is a chromosomal passenger protein associated with centromeres, the spindle midzone, and poles during mitosis and the cleavage furrow during cytokinesis. Disruption of the single DdINCENP gene revealed important roles for this protein in mitosis and cytokinesis. DdINCENP null cells lack a robust spindle midzone and are hypersensitive to microtubule-depolymerizing drugs, suggesting that their spindles may not be stable. Furthermore DdCP224, a protein homologous to the… CONTINUE READING