Contractile responses to selective phosphodiesterase inhibitors following chronic β-adrenoreceptor activation

@article{Osadchii2005ContractileRT,
  title={Contractile responses to selective phosphodiesterase inhibitors following chronic β-adrenoreceptor activation},
  author={Oleg E Osadchii and Angela Jill Woodiwiss and Gavin Robert Norton},
  journal={Pfl{\"u}gers Archiv},
  year={2005},
  volume={452},
  pages={155-163}
}
Contractile responses to phosphodiesterase (PDE) inhibitors are attenuated in heart failure, an effect limiting the clinical value of these agents. In this study, we sought to determine whether abnormalities in the β-adrenoreceptor (β-AR)–cyclic adenosine monophosphate (cAMP) signal transduction are sufficient to account for downregulation of PDE inhibitor-induced inotropic responses following chronic sympathetic activation. Sustained β-AR activation produced by administration of isoproterenol… CONTINUE READING
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