Contractile mechanisms of action of gastroprokinetic agents: cisapride, metoclopramide, and domperidone.

@article{Orihata1994ContractileMO,
  title={Contractile mechanisms of action of gastroprokinetic agents: cisapride, metoclopramide, and domperidone.},
  author={Michihiro Orihata and Sushil K Sarna},
  journal={The American journal of physiology},
  year={1994},
  volume={266 4 Pt 1},
  pages={G665-76}
}
We investigated the contractile mechanisms of action of three putative gastroprokinetic agents (cisapride, metoclopramide, and domperidone) on the linear phase of gastroduodenal emptying of solid meals in six healthy conscious dogs. The spatial and temporal parameters of gastric, pyloric, and duodenal contractions during the entire period of gastroduodenal emptying, during the 60-min period of drug infusion (ti), and during the postdrug infusion period (tpi) were analyzed by a computer method… CONTINUE READING

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