Contractile function of papillary muscles with carbonic anhydrase inhibitors.

  title={Contractile function of papillary muscles with carbonic anhydrase inhibitors.},
  author={Cornelia Geers and Gerolf Gros},
  journal={Life sciences},
  volume={57 6},
Contractile parameters of directly stimulated rabbit papillary muscles were studied during incubation in baths containing the carbonic anhydrase inhibitors chlorzolamide (1*10(-3) M) or ethoxzolamide (1*10(-4) M). Both inhibitors caused an at least partly reversible decrease in isometric force as it has been observed in skeletal muscle, and--in contrast to the results in skeletal muscles--a decrease in time-to-peak and half-relaxation time. It is postulated that inhibition of the membrane-bound… CONTINUE READING

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