Contractile forces in tumor cell migration.

  title={Contractile forces in tumor cell migration.},
  author={Claudia Tanja Mierke and Daniel R{\"o}sel and Ben Fabry and Jan Br{\'a}bek},
  journal={European journal of cell biology},
  volume={87 8-9},
Cancer is a deadly disease primarily because of the ability of tumor cells to spread from the primary tumor, to invade into the connective tissue, and to form metastases at distant sites. In contrast to cell migration on a planar surface where large cell tractions and contractile forces are not essential, tractions and forces are thought to be crucial for overcoming the resistance and steric hindrance of a dense three-dimensional connective tissue matrix. In this review, we describe recently… CONTINUE READING


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