Contractile effects of endothelin-1 and localization of endothelin binding sites in rabbit lower urinary tract smooth muscle.

@article{GarciaPascual1990ContractileEO,
  title={Contractile effects of endothelin-1 and localization of endothelin binding sites in rabbit lower urinary tract smooth muscle.},
  author={Angeles Garcia-Pascual and Benny Larsson and Karl-Erik Andersson},
  journal={Acta physiologica Scandinavica},
  year={1990},
  volume={140 4},
  pages={545-55}
}
In isolated rabbit bladder and urethral smooth muscle, endothelin-1 caused concentration-related, slowly developing contractions that were difficult to wash out. Relative to contractions induced by K+ (124 mM), contractions in bladder preparations reached a higher amplitude than in urethral preparations. There was a marked tachyphylaxis to the effects of the peptide. The endothelin-1-induced contractions were not significantly affected by phentolamine or indomethacin in the urethra, or by… CONTINUE READING

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Mentioned Connections BETA
Urinary BladderDirect proximal toUrethra
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
Urinary BladderDirect superior toUrethra
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
Urinary BladderDirect continuous withUrethra
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
Urinary BladderSibling in part ofUrethra
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
UrethraSibling in part ofUrinary Bladder
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
Urinary BladderSibling in is aUrethra
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
UrethraSibling in is aUrinary Bladder
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
UrethraContinuous proximally withUrinary Bladder
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
UrethraDirect continuous withUrinary Bladder
Relative to contractions induced by K+ ( 124 mM ) , contractions in bladder preparations reached a higher amplitude than in urethral preparations .
The results suggest that in the rabbit both bladder and urethral smooth muscle contain binding sites for endothelin .
In isolated rabbit bladder and urethral smooth muscle , endothelin-1 caused concentration - related , slowly developing contractions that were difficult to wash out .
Contractile effects of endothelin-1 and localization of endothelin binding sites in rabbit lower urinary tract smooth muscle .
Contractile effects of endothelin-1 and localization of endothelin binding sites in rabbit lower urinary tract smooth muscle .
SubmucosaSibling in is aMuscle layer
In both bladder and urethra , [ 125]endothelin-1 binding sites were found mainly in the outer longitudinal muscle layer , in vessels and in the submucosa .
Muscle layerSibling in is aSubmucosa
In both bladder and urethra , [ 125]endothelin-1 binding sites were found mainly in the outer longitudinal muscle layer , in vessels and in the submucosa .
Muscle layerAnatomic structure is physical part ofUrinary Bladder
In both bladder and urethra , [ 125]endothelin-1 binding sites were found mainly in the outer longitudinal muscle layer , in vessels and in the submucosa .
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