Contractile effects and intracellular Ca2+ signalling induced by emodin in circular smooth muscle cells of rat colon.

@article{Ma2003ContractileEA,
  title={Contractile effects and intracellular Ca2+ signalling induced by emodin in circular smooth muscle cells of rat colon.},
  author={Tao Ma and Qing-hui Qi and Wen-xiu Yang and J Xu and Zuo-Liang Dong},
  journal={World journal of gastroenterology},
  year={2003},
  volume={9 8},
  pages={1804-7}
}
AIM To investigate whether emodin has any effects on circular smooth muscle cells of rat colon and to examine the mechanism underlying its effect. METHODS Smooth muscle cells were isolated from the circular muscle layer of Wistar rat colon and the cell length was measured by computerized image micrometry. Intracellular Ca(2+) ([Ca(2+)]i) signalling was studied in smooth muscle cells using Ca(2+) indicator Fluo-3 AM on a laser-scanning confocal microscope. RESULTS Emodin dose-dependently… CONTINUE READING