Contractile dysfunction of isolated ventricular myocytes in experimental uraemia.

@article{McMahon1996ContractileDO,
  title={Contractile dysfunction of isolated ventricular myocytes in experimental uraemia.},
  author={Anne-Marie McMahon and Giorgio Vescovo and Luciano Dalla Libera and Dylan G. Wynne and Richard J. Fluck and Sian E Harding and Anthony E. G. Raine},
  journal={Experimental nephrology},
  year={1996},
  volume={4 3},
  pages={144-50}
}
In order to clarify the mechanism underlying impaired cardiac performance in uraemia, the contractile function of isolated cardiac myocytes from chronically uraemic and control rats has been compared. Rats were made uraemic by sub-total nephrectomy in a two-stage surgical procedure, and left for 4 weeks. Sham-operated controls were prepared at the same time. Animals were pairfed, and final body weights were not significantly different between the groups. Ventricular myocytes were isolated and… CONTINUE READING