Contractile dysfunction and abnormal Ca2+ modulation during postischemic reperfusion in rat heart.

@article{Meissner1995ContractileDA,
  title={Contractile dysfunction and abnormal Ca2+ modulation during postischemic reperfusion in rat heart.},
  author={Andreas Meissner and James Plunkett Morgan},
  journal={The American journal of physiology},
  year={1995},
  volume={268 1 Pt 2},
  pages={H100-11}
}
Isolated adult rat hearts in an isovolumic nonworking Langendorff preparation were loaded with the Ca2+ indicator aequorin to investigate the effects of ischemic reperfusion on free intracellular Ca2+ concentration ([Ca2+]i) homeostasis and left ventricular (LV) contractile function. In three groups (each n = 8) that underwent 10, 20, and 30 min of ischemia, recovery of developed pressure amounted to, respectively, 63% [77 +/- 3 (SE) mmHg], 48% (56 +/- 4 mmHg), and 34% (43 +/- 4 mmHg) of… CONTINUE READING

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