Contractile and chemosensitive properties of muscle treated with calcium ionophore A23187. Comparison with dystrophic muscle.


Rat diaphragms were treated with calcium ionophore, A23187, for 60 min at 37 degrees C, and twitch, tetanus and their derivatives were studied on the basis of the active state concept. Results were than compared with those of human dystrophic muscle. Like dystrophic muscle, maximum tetanic force and maximum velocity of tetanus development were markedly… (More)


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