Contractile and Vasorelaxant Effects of Hydrogen Sulfide and Its Biosynthesis in the Human Internal Mammary Artery

  title={Contractile and Vasorelaxant Effects of Hydrogen Sulfide and Its Biosynthesis in the Human Internal Mammary Artery},
  author={G. D. Webb and L. H. Lim and V. Oh and S. Yeo and Y. Cheong and Muhammed Yusuf Ali and R. El Oakley and C. Lee and P. Wong and M. Caleb and M. Salto-Tellez and M. Bhatia and E. S. Y. Chan and E. Taylor and P. Moore},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={876 - 882}
This study aimed to test these hypotheses: cystathionine γ-lyase (CSE) is expressed in a human artery, it generates hydrogen sulfide (H2S), and H2S relaxes a human artery. H2S is produced endogenously in rat arteries from cysteine by CSE. Endogenously produced H2S dilates rat resistance arteries. Although CSE is expressed in rat arteries, its presence in human blood vessels has not been described. In this study, we showed that both CSE mRNA, determined by reverse transcription-polymerase chain… Expand
Vasorelaxation elicited by endogenous and exogenous hydrogen sulfide in mouse mesenteric arteries
  • J. Hart
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2019
Hydrogen sulfide-mediated endothelial function and the interaction with eNOS and PDE5A activity in human internal mammary arteries
Mechanism of vasorelaxation and role of endogenous hydrogen sulfide production in mouse aorta
Hydrogen Sulfide-Induced Dual Vascular Effect Involves Arachidonic Acid Cascade in Rat Mesenteric Arterial Bed
H2S and Blood Vessels: An Overview.
Hydrogen sulfide (H2S): the new member of gasotransmitter family
Hydrogen sulphide in heart and systemic circulation.


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  • Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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