Contractile and Vasorelaxant Effects of Hydrogen Sulfide and Its Biosynthesis in the Human Internal Mammary Artery

@article{Webb2008ContractileAV,
  title={Contractile and Vasorelaxant Effects of Hydrogen Sulfide and Its Biosynthesis in the Human Internal Mammary Artery},
  author={G. D. Webb and L. H. Lim and V. Oh and S. Yeo and Y. Cheong and Muhammed Yusuf Ali and R. El Oakley and C. Lee and P. Wong and M. Caleb and M. Salto-Tellez and M. Bhatia and E. S. Y. Chan and E. Taylor and P. Moore},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={324},
  pages={876 - 882}
}
This study aimed to test these hypotheses: cystathionine γ-lyase (CSE) is expressed in a human artery, it generates hydrogen sulfide (H2S), and H2S relaxes a human artery. H2S is produced endogenously in rat arteries from cysteine by CSE. Endogenously produced H2S dilates rat resistance arteries. Although CSE is expressed in rat arteries, its presence in human blood vessels has not been described. In this study, we showed that both CSE mRNA, determined by reverse transcription-polymerase chain… Expand
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