Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner

@inproceedings{Hong2017ContractileAA,
  title={Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner},
  author={Jinsung Hong and Sricharan Murugesan and Eric Betzig and John A Hammer},
  booktitle={PloS one},
  year={2017}
}
Mechano-transduction is an emerging but still poorly understood component of T cell activation. Here we investigated the ligand-dependent contribution made by contractile actomyosin arcs populating the peripheral supramolecular activation cluster (pSMAC) region of the immunological synapse (IS) to T cell receptor (TCR) microcluster transport and proximal signaling in primary mouse T cells. Using super resolution microscopy, OT1-CD8+ mouse T cells, and two ovalbumin (OVA) peptides with different… CONTINUE READING
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