Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function

@inproceedings{Birket2015ContractileDC,
  title={Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function},
  author={Matthew J. Birket and Marcelo C Ribeiro and Georgios Kosmidis and Dorien Ward and Ana Rita Canhoto Leitoguinho and Vera van de Pol and Cheryl Dambrot and Harsha D Devalla and Richard P Davis and Pier G. Mastroberardino and Douwe Ekke Atsma and Robert Passier and Christine L Mummery},
  booktitle={Cell reports},
  year={2015}
}
Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate level of function to permit robust single-cell contractility measurements in a human induced pluripotent stem cell (hiPSC) model of hypertrophic cardiomyopathy (HCM). A simple screen revealed the collaborative effects of thyroid hormone, IGF-1 and the… CONTINUE READING
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