Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9

@inproceedings{Reynolds2012ContractileBN,
  title={Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9},
  author={Stephen E. Reynolds and Ashley Williams and Heather Williams and Shaun Smale and Heather Stephenson and Nathaniel Scott Amos and Sj George and Vincent O'donnell and Derek C. Lang},
  booktitle={British journal of pharmacology},
  year={2012}
}
BACKGROUND AND PURPOSE Excess morbidity/mortality in rheumatoid arthritis (RA) is associated with increased incidence of cardiovascular disease. In this 'proof-of-concept' study, vascular function was characterized in the murine collagen-induced arthritis (mCIA) model, the benchmark choice for evaluation of the pathological processes and assessment of new therapies. EXPERIMENTAL APPROACH Mice in the very early stages of arthritis development [and appropriate naïve (non-immunized) age-matched… CONTINUE READING
BETA

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