Contractile, biochemical, and histochemical properties of thyrotoxic rat soleus muscle.

@article{Fitts1980ContractileBA,
  title={Contractile, biochemical, and histochemical properties of thyrotoxic rat soleus muscle.},
  author={Robert H Fitts and William Winder and Michael H Brooke and Karl-Heinz Kaiser and John O. Holloszy},
  journal={The American journal of physiology},
  year={1980},
  volume={238 1},
  pages={C14-20}
}
The effects of thyrotoxicosis on the contractile properties of soleus muscle were examined in rats given 3 mg of T4 and 1 mg of T3 per kg of diet for 6--8 wk. Thyrotoxicosis induced significant decreases in isometric twitch contraction time (CT), one-half relaxation time, and peak twitch tension. The Ca2+ uptake activity of the sarcoplasmic reticulum (SR) was increased in the thyrotoxic muscles; this adaptation in the SR provides a possible mechanism for the alterations in isometric contractile… CONTINUE READING

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