Contortrostatin, a homodimeric disintegrin, binds to integrin alphavbeta5.

  title={Contortrostatin, a homodimeric disintegrin, binds to integrin alphavbeta5.},
  author={Q. F. Zhou and Marian T. Nakada and P. C. Brooks and Stephen D. Swenson and Matthew R Ritter and S Argounova and Catherine Arnold and Francis S. Markland},
  journal={Biochemical and biophysical research communications},
  volume={267 1},
Contortrostatin is a homodimeric disintegrin from snake venom. We have shown that contortrostatin binds to integrins alphaIIbbeta3, alpha5beta1, and alphavbeta3. We now use several criteria to demonstrate the binding of contortrostatin to alphavbeta5. First, incubation of T24 cells, which express alphavbeta3 and alphavbeta5, with antibody against alphavbeta3 failed to completely inhibit adhesion of cells to vitronectin. However, pretreatment of the cells with contortrostatin or the combination… CONTINUE READING