Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis

@article{Zhou1999ContortrostatinAD,
  title={Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis},
  author={Qing Sheng Zhou and Marian T. Nakada and Catherine Arnold and Kate Y. Shieh and Francis S. Markland},
  journal={Angiogenesis},
  year={1999},
  volume={3},
  pages={259-269}
}
Contortrostatin, a 13.5 kDa disulfide-linked homodimeric polypeptide possessing an Arg–Gly–Asp sequence, was isolated from venom of the southern copperhead snake. Daily injection of contortrostatin into the primary tumor of human breast cancer MDA-MB-435 carried in nude mice significantly inhibited tumor growth and neovascularization of the tumor tissue. On the chick embryo chorioallantoic membrane, contortrostatin inhibited angiogenesis induced by MDA-MB-435 cells, basic fibroblast growth… CONTINUE READING

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Prognostic signi®cance of tumor vascularity

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