Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.

@article{Legname2006ContinuumOP,
  title={Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.},
  author={Giuseppe Legname and H B Nguyen and David J Peretz and Fred E. Cohen and Stephen J. DeArmond and Stanley B Prusiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 50},
  pages={19105-10}
}
On passaging synthetic prions, two isolates emerged with incubation times differing by nearly 100 days. Using conformational-stability assays, we determined the guanidine hydrochloride (Gdn.HCl) concentration required to denature 50% of disease-causing prion protein (PrP(Sc)) molecules, denoted as the [Gdn.HCl](1/2) value. For the two prion isolates enciphering shorter and longer incubation times, [Gdn.HCl](1/2) values of 2.9 and 3.7 M, respectively, were found. Intrigued by this result, we… CONTINUE READING
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