Continuous time boolean modeling for biological signaling: application of Gillespie algorithm

  title={Continuous time boolean modeling for biological signaling: application of Gillespie algorithm},
  author={Gautier Stoll and Eric Viara and Emmanuel Barillot and Laurence Calzone},
  booktitle={BMC Systems Biology},
Mathematical modeling is used as a Systems Biology tool to answer biological questions, and more precisely, to validate a network that describes biological observations and predict the effect of perturbations. This article presents an algorithm for modeling biological networks in a discrete framework with continuous time. There exist two major types of mathematical modeling approaches: (1) quantitative modeling, representing various chemical species concentrations by real numbers, mainly based… CONTINUE READING
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