Continuous subcutaneous administration of mesna to prevent ifosfamide-induced hemorrhagic cystitis.

@article{Markman1996ContinuousSA,
  title={Continuous subcutaneous administration of mesna to prevent ifosfamide-induced hemorrhagic cystitis.},
  author={Maurie Markman and A W Kennedy and Kenneth D. Webster and Barbara Kulp and Gertrude Peterson and Jerome Leslie Belinson},
  journal={Seminars in oncology},
  year={1996},
  volume={23 3 Suppl 6},
  pages={97-8}
}
Hemorrhagic cystitis is a major potential toxicity of ifosfamide that can be prevented by administering mesna along with the cytotoxic agent. Mesna is generally administered by the intravenous route, although experience with oral delivery of the drug has increased. The continuous subcutaneous administration of mesna has the advantage of not requiring intravenous access. In addition, subcutaneous delivery of the neutralizing agent will not be associated with the risk of inadequate urinary mesna… CONTINUE READING

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