Continuous production of erythropoietin with immobilized animal cells


Erythropoietin, a glycoprotein that is a physiological stimulator of erythrocyte production, was produced continuously for more than 32 days by three kinds of anchorage-dependent animal cells immobilized in alginate gel particles. Gelation caused by divalent cations added to an alginate solution containing cells resulted in the formation of clearly vacant… (More)
DOI: 10.1007/BF00260982


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@article{Shirai2004ContinuousPO, title={Continuous production of erythropoietin with immobilized animal cells}, author={Yoshihito Shirai and Ryuzo Sasaki and Kenji Hashimoto and Hiroyuki Kawahara and Kiyotaka Hitomi and Hideo Chiba}, journal={Applied Microbiology and Biotechnology}, year={2004}, volume={29}, pages={544-549} }