• Chemistry, Medicine
  • Published in Arzneimittel-Forschung 1987

Continuous-plus-on-demand epidural infusion of buprenorphine versus morphine in postoperative treatment of pain. Postoperative epidural infusion of buprenorphine.

@article{Chrubasik1987ContinuousplusondemandEI,
  title={Continuous-plus-on-demand epidural infusion of buprenorphine versus morphine in postoperative treatment of pain. Postoperative epidural infusion of buprenorphine.},
  author={Joachim Chrubasik and Wolfgang H. Vogel and H. Tr{\"o}tschler and Eduard Heinrich Farthmann},
  journal={Arzneimittel-Forschung},
  year={1987},
  volume={37 3},
  pages={
          361-3
        }
}
In a randomized, double-blind study, buprenorphine was compared with morphine in the treatment of pain after major abdominal operations by means of continuous-plus-on-demand epidural infusion for constant analgesia. The patients received bolus epidural injections of 0.15 mg buprenorphine or 2 mg morphine-HCl prior to an on-demand epidural infusion of 0.03% buprenorphine or 0.25% morphine HCl at a basal rate of 0.06 ml/h. Over 50 h, mean buprenorphine consumption was 0.85 +/- 0.08 mg, and mean… CONTINUE READING

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