Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe.

@article{Vajkoczy2000ContinuousMO,
  title={Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe.},
  author={Peter Vajkoczy and Harry Roth and Peter Horn and Thomas Lucke and Claudius Thom{\'e} and U Hubner and Gregory T. Martin and C Zappletal and E. Klar and Lothar Schilling and Peter Schmiedek},
  journal={Journal of neurosurgery},
  year={2000},
  volume={93 2},
  pages={
          265-74
        }
}
OBJECT Current clinical neuromonitoring techniques lack adequate surveillance of cerebral perfusion. In this article, a novel thermal diffusion (TD) microprobe is evaluated for the continuous and quantitative assessment of intraparenchymal regional cerebral blood flow (rCBF). METHODS To characterize the temporal resolution of this new technique, rCBF measured using the TD microprobe (TD-rCBF) was compared with rCBF levels measured by laser Doppler (LD) flowmetry during standardized variations… 

Figures and Tables from this paper

Correlation of continuously monitored regional cerebral blood flow and brain tissue oxygen

The level of PtiO2 seems to be predominately determined by regional CBF, since changes in Pti O2 were correlated in 90% of episodes to simultaneous changes of CBF.

Evaluation of a New Brain Tissue Probe for Cerebral Blood Flow Monitoring in an Experimental Pig Model.

Assessment of a new brain tissue probe for serial CBF monitoring using near-infrared spectroscopy and indocyanine green dye dilution compared with the existing thermal diffusion probe found the NeMo Probe provides acceptable trending ability and reproducecibility from repeated measurements, whereas the reproducibility of the QFlow 500 Probe was poor.

Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following aneurysmal subarachnoid hemorrhage.

Thermal-diffusion flowmetry represents a promising method for the bedside monitoring of patients with SAH to detect symptomatic vasospasm and was characterized by a more favorable diagnostic reliability than transcranial Doppler ultrasonography.

Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats

The laser Doppler technique provides a reliable method for detection of a wide range of cerebral blood flow changes under CO2 challenge and is validated for assessment of cerebral autoregulation and CO2 reactivity with the 133xenon injection technique as the gold standard.

Reproducibility of the blood flow index as noninvasive, bedside estimation of cerebral blood flow

As a relative but not absolute measure of CBF, BFI seems to be suited for clinical evaluation of intraindividual CBF changes during determination of cerebrovascular reactivities or during therapeutic interventions.

Evaluation of a Novel Brain Tissue Oxygenation Probe in an Experimental Swine Model

It is questionable whether existing knowledge of Licox tissue oxygenation, ie, hypoxic threshold, can be directly transferred to the Neurovent-TO device, which comparably measures PbrO2 under most conditions tested compared with the Licox device.

Continuous Thermal Diffusion-Based Cerebral Blood Flow Monitoring in Adult Traumatic Brain Injury: A Scoping Systematic Review.

A systematic review of TDF-regional(r)CBF measurements and their association with patient functional outcome, other neurophysiological parameters, and imaging-based tissue outcomes suggests a link between sustained low or high CBF and poor functional outcome.

Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods

The comprehensive description of principles, methods, and clinical requirements of CBF and CA measurements highlights the potentially important role that noninvasive optical methods can play in the assessment of neurovascular health.

Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults

The potential for DCS to provide continuous, noninvasive bedside monitoring for the purpose of CBF management and individualized care is demonstrated.
...

References

SHOWING 1-10 OF 50 REFERENCES

Monitoring of regional cerebral blood flow (CBF) in acute head injury by thermal diffusion.

The results indicate that continuous monitoring of CBF with the thermal diffusion method as currently used cannot be used in the clinical management of the patient.

Continuous Measurement of Cerebral Cortical Blood Flow by Laser—Doppler Flowmetry in a Rat Stroke Model

It is concluded that LDF does not provide accurate measurements of absolute rCBF values but this method allows accurately measurements of changes in r CBF due to induction of focal cerebral ischemia.

Repeated measurements of cerebral blood flow in rats. Comparisons between the hydrogen clearance method and laser Doppler flowmetry.

The laser Doppler method seems to be most useful for continuous estimations of changes in cerebral blood flow, and the depth sensitivity of LDFM in the brain may be greater than expected.

Application of laser Doppler flowmetry in neurosurgery.

Cerebral Blood Flow in Rats During Physiological and Humoral Stimuli

These studies indicate that initial slope estimates of CBF derived in rats from intracarotid 123Xe injection, which represents an inexpensive and simplified approach for screening cerebral circulatory adjustments, may facilitate the characterization of stimuli affecting CBF.

Continuous regional cerebral cortical blood flow monitoring in head-injured patients.

Continuous rCoBF monitoring in head-injured patients offers new therapeutic and prognostic insights into their management and changes were statistically significant when management was based strictly upon the intracranial pressure.

Cortical thermal clearance as a predictor of imminent neurological deterioration.

  • M. Choksey
  • Medicine
    Cerebrovascular and brain metabolism reviews
  • 1996
The cortical thermal clearance (CTC) was monitored postoperatively in 24 patients after aneurysm surgery and it was seen that a low-or falling-thermal clearance was associated with development of a neurological deficit, whereas all patients with a CTC below 35 did.

Continuous regional cerebral blood flow monitoring in acute craniocerebral trauma.

The early detection of ischemic or hyperemic responses by continuous CBF monitoring could hasten intervention aimed at restoring adequate tissue perfusion and is suitable to gain more insight into the pathophysiology of head injury, especially the relationship of CBF to ICP.

Correlation of Transcranial Doppler Sonography Mean Flow Velocity with Cerebral Blood Flow in Patients with Intracranial Pathology

The close correlation between changes in CBF and Vm in patients with heterogenous intracranial pathology seems to show that TCD is a measure of CBF, but in groups 1 and 2 and in subgroups formed of patients classified according to diagnoses, data dispersion suggests that the actual correlation is weaker.

Brain oxygen, CO2, pH, and temperature monitoring: evaluation in the feline brain.

Continuous monitoring of oxygen, CO2, pH, and temperature in damaged or at-risk brain tissue using a single sensor is now feasible and will, thus, allow improved continuous monitoring of neurosurgical patients who are at risk of significant secondary brain damage.