Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity.

@article{Klement2000ContinuousLT,
  title={Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity.},
  author={Giannoula Klement and Sylvain Baruchel and Janusz Rak and Shuli Man and Kimberly Clark and Daniel J. Hicklin and Peter Bohlen and Robert S. Kerbel},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={105 8},
  pages={R15-24}
}
Various conventional chemotherapeutic drugs can block angiogenesis or even kill activated, dividing endothelial cells. Such effects may contribute to the antitumor efficacy of chemotherapy in vivo and may delay or prevent the acquisition of drug-resistance by cancer cells. We have implemented a treatment regimen that augments the potential antivascular effects of chemotherapy, that is devoid of obvious toxic side effects, and that obstructs the development of drug resistance by tumor cells… CONTINUE READING
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