Continuous intraventricular infusion of pentosan polysulfate: clinical trial against prion diseases.

@article{Tsuboi2009ContinuousII,
  title={Continuous intraventricular infusion of pentosan polysulfate: clinical trial against prion diseases.},
  author={Yoshio Tsuboi and Katsumi Doh-Ura and Tatsuo Yamada},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  year={2009},
  volume={29 5},
  pages={632-6}
}
Prion diseases are progressive neurological disorders due to abnormal prion protein (PrP(Sc)) deposition in the central nervous system. At present, there is no effective treatment available for any form of prion disease. Pentosan polysulfate (PPS) has been shown to prolong significantly the incubation period in mice with PrP(Sc) infection when administered to the cerebral ventricles in preclinical trials. In human studies conducted in European countries and Japan, intraventricular PPS was… CONTINUE READING