Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial.

@article{Badesch2000ContinuousIE,
  title={Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial.},
  author={David B. Badesch and Victor F. Tapson and M Mcgoon and Bruce H. Brundage and Lewis J. Rubin and F M Wigley and Sharon Rich and Robyn J. Barst and Pamela S. Barrett and Kenneth M Kral and Maria M J{\"o}bsis and James E Loyd and Sathya Murali and Adaani Frost and R. Girgis and Robert C Bourge and David D. Ralph and Charles Gregory Elliott and Nicholas S Hill and David Langleben and Robert J. Schilz and Vallerie V Mclaughlin and Ivan M. Robbins and B. M. Groves and S. Shapiro and Thomas A Jr Medsger},
  journal={Annals of internal medicine},
  year={2000},
  volume={132 6},
  pages={425-34}
}
Pulmonary hypertension is characterized by progressive elevation of pulmonary artery pressure and vascular resistance, often leading to right ventricular failure and death (1-3). Continuous intravenous infusion of epoprostenol improves prognosis and symptoms in patients with primary (idiopathic) pulmonary hypertension (4-8). Randomized, controlled clinical trials of epoprostenol for secondary pulmonary hypertension have not been conducted. Pulmonary hypertension frequently complicates the… CONTINUE READING
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