Continuous infusion versus intermittent administration of meropenem in critically ill patients.

@article{Thalhammer1999ContinuousIV,
  title={Continuous infusion versus intermittent administration of meropenem in critically ill patients.},
  author={Florian Thalhammer and Friederike Traunmueller and Ibrahim El Menyawi and Michael Frass and U M Hollenstein and G J Locker and Brigitte Stoiser and Thomas Staudinger and Renate Thalhammer-Scherrer and Heinz Burgmann},
  journal={The Journal of antimicrobial chemotherapy},
  year={1999},
  volume={43 4},
  pages={523-7}
}
This prospective crossover study compared the pharmacokinetics of meropenem by continuous infusion and by intermittent administration in critically ill patients. Fifteen patients were randomized to receive meropenem either as a 2 g iv loading dose, followed by a 3 g continuous infusion (CI) over 24 h, or by intermittent administration (IA) of 2 g iv every 8 h (q8h). Each regimen was followed for a period of 2 days, succeeded by crossover to the alternative regimen for the same period… CONTINUE READING