Continuous infusion of insulin-like growth factor-I into the epiphysis of the tibia

@article{Abbaspour2007ContinuousIO,
  title={Continuous infusion of insulin-like growth factor-I into the epiphysis of the tibia},
  author={Aziz Abbaspour and Shinjiro Takata and Yoshito Matsui and Shinsuke Katoh and Mitsuhiko Takahashi and Natsuo Yasui},
  journal={International Orthopaedics},
  year={2007},
  volume={32},
  pages={395-402}
}
We have developed a method to promote longitudinal bone growth at the level of a specific growth-plate (GP) in young rabbits. Insulin-like growth factor-I (IGF-I) was continuously infused by means of an osmotic pump into the bone marrow cavity of the proximal epiphysis of the tibia. Radiological measurement showed a 2-mm overgrowth of the tibia after 4 weeks of treatment, while histological analysis demonstrated a 15% increase in the thickness of the selected GP. The local infusion of IGF-I… CONTINUE READING

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