Continuous infusion of ceftazidime with a portable pump is as effective as thrice-a-day bolus in cystic fibrosis children

@article{Rappaz2000ContinuousIO,
  title={Continuous infusion of ceftazidime with a portable pump is as effective as thrice-a-day bolus in cystic fibrosis children},
  author={Isabelle Rappaz and Laurent A Decosterd and Jacques Bille and Marianne Pilet and Nicole B{\'e}laz and Michel Roulet},
  journal={European Journal of Pediatrics},
  year={2000},
  volume={159},
  pages={919-925}
}
Continuous infusion (CI) of β-lactam antibiotics provides a stable concentration which may result in a better activity against gram-negative bacteria if exceeding the minimum inhibitory concentration (MIC). Treatment outcome after 24 h CI of ceftazidime (CAZ) in cystic fibrosis (CF) children was compared with the bolus administration regimen. Fourteen CF children with chronic Pseudomonas aeruginosa pulmonary infection were treated during 14 days with the conventional CAZ thrice-a-day bolus… CONTINUE READING

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