Continuous-infusion cisplatin, 5-fluorouracil, and bolus methotrexate in the treatment of advanced non-small cell lung cancer.

Abstract

BACKGROUND Cisplatin and 5-fluorouracil have noted synergy in preclinical systems. The authors combined methotrexate with infusional cisplatin and 5-fluorouracil in an attempt to produce a regimen with improved activity in advanced NSCLC: METHODS Twenty-six ambulatory patients with previously untreated non-small cell lung cancer were treated with… (More)

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Cite this paper

@article{Lynch1992ContinuousinfusionC5, title={Continuous-infusion cisplatin, 5-fluorouracil, and bolus methotrexate in the treatment of advanced non-small cell lung cancer.}, author={Tom J. Lynch and Jonathan Clark and Leslie A. Kalish and Barbara Fallon and A D Elias and Arthur T. Skarin and Emil Frei}, journal={Cancer}, year={1992}, volume={70 7}, pages={1880-5} }