Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial

@article{Saunders1997ContinuousHA,
  title={Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial},
  author={M. Saunders and S. Dische and A. Barrett and Angela Harvey and on behalf of the Chart Steering Committee},
  journal={The Lancet},
  year={1997},
  volume={350},
  pages={161-165}
}
  • M. Saunders, S. Dische, +2 authors on behalf of the Chart Steering Committee
  • Published 1997
  • Medicine
  • The Lancet
  • BACKGROUND Human tumour cells can proliferate rapidly, and giving radiotherapy in many small fractions may reduce long-term normal-tissue morbidity. [...] Key Method We included patients with NSCLC localised to the chest with a performance status of 0 or 1 in whom radical radiotherapy was chosen as the definitive management. Patients were randomly allocated in a 3:2 ratio to CHART or conventional radiotherapy. The latter was thirty fractions of 2 Gy to a total dose of 60 Gy in 6 weeks. Expand Abstract
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