Continuous flow nucleophilic aromatic substitution with dimethylamine generated in situ by decomposition of DMF.

@article{Petersen2013ContinuousFN,
  title={Continuous flow nucleophilic aromatic substitution with dimethylamine generated in situ by decomposition of DMF.},
  author={Trine P. Petersen and Anders Foller Larsen and Andreas Ritz{\'e}n and Trond Ulven},
  journal={The Journal of organic chemistry},
  year={2013},
  volume={78 8},
  pages={4190-5}
}
A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.