Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.

@article{AbuElheiga2001ContinuousFA,
  title={Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.},
  author={Lutfi Abu-Elheiga and Martin M. Matzuk and K A Abo-Hashema and Salih J. Wakil},
  journal={Science},
  year={2001},
  volume={291 5513},
  pages={2613-6}
}
Malonyl-coenzyme A (malonyl-CoA), generated by acetyl-CoA carboxylases ACC1 and ACC2, is a key metabolite in the regulation of energy homeostasis. Here, we show that Acc2-/- mutant mice have a normal life span, a higher fatty acid oxidation rate, and lower amounts of fat. In comparison to the wild type, Acc2-deficient mice had 10- and 30-fold lower levels of malonyl-CoA in heart and muscle, respectively. The fatty acid oxidation rate in the soleus muscle of the Acc2-/- mice was 30% higher than… CONTINUE READING
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