Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes

@article{KeenRhinehart2009ContinuousEO,
  title={Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes},
  author={Erin Keen-Rhinehart and Vasiliki J. Michopoulos and Donna J Toufexis and Elizabeth I Martin and Harikrishnan M Nair and Kerry J. Ressler and Michael L Davis and Michael J. Owens and Charles B. Nemeroff and Melinda E. Wilson},
  journal={Molecular Psychiatry},
  year={2009},
  volume={14},
  pages={37-50}
}
An increase in corticotropin-releasing factor (CRF) is a putative factor in the pathophysiology of stress-related disorders. As CRF expression in the central nucleus of the amygdala (CeA) is important in adaptation to chronic stress, we hypothesized that unrestrained synthesis of CRF in CeA would mimic the consequences of chronic stress exposure and cause dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, increase emotionality and disrupt reproduction. To test this hypothesis, we… CONTINUE READING

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