Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.

M. D. Kuwahara; S. Sparber

DOI:10.1159/000457417

Corpus ID: 9658954

Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.

@article{Kuwahara1981ContinuousEO,
  title={Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.},
  author={M. D. Kuwahara and S. Sparber},
  journal={Developmental pharmacology and therapeutics},
  year={1981},
  volume={3 1},
  pages={
          12-24
        }
}

M. D. Kuwahara, S. Sparber

Published 1981

Biology, Medicine

Developmental pharmacology and therapeutics

Injection of l-alpha-noracetylmethadol (NLAAM), the active des-methyl metabolite of l-alpha-acetylmethadol, into chicken eggs on the 3rd day of embryonic development produced no deficits in body or brain weight, or brain nucleic acid and protein content in the 20-day check embryo. NLAAM decreased embryo viability in a dose-dependent manner as early as day 4. At this time measureable levels of radiolabeled NLAAM could be detected in the embryo; further sampling of whole embryos or embryo brains… CONTINUE READING

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