Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.

@article{Kuwahara1981ContinuousEO,
  title={Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.},
  author={M. D. Kuwahara and S. Sparber},
  journal={Developmental pharmacology and therapeutics},
  year={1981},
  volume={3 1},
  pages={
          12-24
        }
}
  • M. D. Kuwahara, S. Sparber
  • Published 1981
  • Biology, Medicine
  • Developmental pharmacology and therapeutics
  • Injection of l-alpha-noracetylmethadol (NLAAM), the active des-methyl metabolite of l-alpha-acetylmethadol, into chicken eggs on the 3rd day of embryonic development produced no deficits in body or brain weight, or brain nucleic acid and protein content in the 20-day check embryo. NLAAM decreased embryo viability in a dose-dependent manner as early as day 4. At this time measureable levels of radiolabeled NLAAM could be detected in the embryo; further sampling of whole embryos or embryo brains… CONTINUE READING
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