Continuous dissolution of structure during the unfolding of a small protein.

  title={Continuous dissolution of structure during the unfolding of a small protein.},
  author={Santosh Kumar Jha and Deepak Dhar and Guruswamy Krishnamoorthy and Jayant B Udgaonkar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 27},
The unfolding kinetics of many small proteins appears to be first order, when measured by ensemble-averaging probes such as fluorescence and circular dichroism. For one such protein, monellin, it is shown here that hidden behind this deceptive simplicity is a complexity that becomes evident with the use of experimental probes that are able to discriminate between different conformations in an ensemble of structures. In this study, the unfolding of monellin has been probed by measurement of the… CONTINUE READING

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