Continuous differential impedance spectroscopy of single cells

  title={Continuous differential impedance spectroscopy of single cells},
  author={Daniele Malleo and J. Tanner Nevill and Luke P. Lee and Hywel Morgan},
  booktitle={Microfluidics and nanofluidics},
A device for continuous differential impedance analysis of single cells held by a hydrodynamic cell trapping is presented. Measurements are accomplished by recording the current from two closely-situated electrode pairs, one empty (reference) and one containing a cell. We demonstrate time-dependent measurement of single cell impedance produced in response to dynamic chemical perturbations. First, the system is used to assay the response of HeLa cells to the effects of the surfactant Tween… CONTINUE READING


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