Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.

@article{Jung2004ContinuousCI,
  title={Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.},
  author={Keun-Hwa Jung and Kon Chu and Manho Kim and S. Jeong and Young-Mok Song and Sang Kun Lee and Jin-Young Kim and J N Roh},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 12},
  pages={3219-26}
}
Brief or prolonged seizures induce various patterns of plasticity. Axonal or dendritic remodelling and development of ectopic granule cells have been described in the hilus and molecular layer of the adult rodent hippocampus. Hippocampal cell proliferation also occurs after seizures. However, whether the seizure-induced cell proliferation plays a pathological or reparative role in the epileptic brain is unknown. In this study, we attempted to suppress the seizure-induced cell proliferation with… CONTINUE READING